Inaoka T, Shuke N, Sato J, Ishikawa Y, Takahashi K, Aburano T, Makita Y
Department of Radiology, Asahikawa Medical College, Japan.
Clin Nucl Med. 2001 Aug;26(8):680-2. doi: 10.1097/00003072-200108000-00003.
A 27-year-old woman with progressive diaphyseal dysplasia (Camurati-Engelmann disease) received pamidronate and corticosteroid therapy for bone pain. During therapy, disease activity was assessed serially using bone scintigraphy with Tc-99m HMDP. With pamidronate administration, the bone pain became worse and diaphyseal uptake of Tc-99m HMDP increased, whereas corticosteroid administration improved the bone pain and reduced the diaphyseal uptake. In this case, pamidronate and corticosteroid produced different effects. Bone scintigraphy allowed an objective assessment of the response to these treatments, accurately reflecting clinical symptoms.
一名患有进行性骨干发育异常（卡穆拉蒂-恩格尔曼病）的27岁女性因骨痛接受了帕米膦酸盐和皮质类固醇治疗。治疗期间，连续使用锝-99m亚甲基二膦酸盐（Tc-99m HMDP）骨闪烁显像评估疾病活动度。给予帕米膦酸盐后，骨痛加重，骨干对Tc-99m HMDP的摄取增加，而给予皮质类固醇后，骨痛改善，骨干摄取减少。在该病例中，帕米膦酸盐和皮质类固醇产生了不同的效果。骨闪烁显像能够客观评估对这些治疗的反应，准确反映临床症状。
