胰岛素自身免疫综合征伴与胰岛素原交叉反应的胰岛素自身抗体导致的严重低血糖症。

Severe hypoglycemia due to insulin autoimmune syndrome with insulin autoantibodies crossreactive to proinsulin.

作者信息

Lohmann T, Kratzsch J, Kellner K, Witzigmann H, Hauss J, Paschke R

机构信息

Department of Internal Medicine III, University of Leipzig, Germany.

出版信息

Exp Clin Endocrinol Diabetes. 2001;109(4):245-8. doi: 10.1055/s-2001-15113.

DOI:10.1055/s-2001-15113

PMID:11453038

Abstract

We report the case of a 69-year-old woman with insulin autoimmune syndrome first misdiagnosed as insulinoma. The case demonstrates the difficulties to correctly diagnose this rare disorder as both insulin and proinsulin levels were increased by crossreactive autoantibodies. No known triggering agent could be identified. We suggest that this diagnosis should be considered more often also in caucasian patients to avoid useless operations for such patients.

摘要

我们报告了一例69岁女性胰岛素自身免疫综合征的病例，该病例最初被误诊为胰岛素瘤。该病例表明，由于交叉反应性自身抗体导致胰岛素和胰岛素原水平均升高，正确诊断这种罕见疾病存在困难。未发现已知的触发因素。我们建议，在白种人患者中也应更频繁地考虑这一诊断，以避免对此类患者进行不必要的手术。