Larsson A, Skoog I, Arlig A, Jacobsson L, Larsson L, Ostling S, Wikkelsö C
Section of Neurology, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Göteborg University, Sweden.
Nucl Med Commun. 2001 Jul;22(7):741-6. doi: 10.1097/00006231-200107000-00003.
Age-related changes in cerebral blood flow (CBF) were examined with [99Tc(m)]-d,l-hexamethylpropylene amine oxime (HMPAO), using a single photon emission tomography (SPET) gamma camera system equipped with a high resolution collimator, in 33 normal individuals in three age groups: 40 years old (n = 11), 75 years old (n = 9) and 88 years old (n = 13). A standard activity of 1000 MBq [99Tc(m)]-d,l-HMPAO was administered. Regional CBF (rCBF) (relative to cerebellar counts) was quantified in 28 grey and white matter regions. The mean rCBF of all the regions was 0.80 (95% confidence interval [CI] 0.77-0.83) in 40 year olds, 0.77 (0.74-0.80) in 75 year olds and 0.76 (0.73-0.78) in 88 year olds. rCBF in the hippocampus, angular and cingular gyri, and frontal association and motor cortices was 5-10% lower in the 75 and 88 year olds than in the middle-aged subjects (P < 0.05). The annual reduction in rCBF was 0.10% between the ages of 40 and 75 years and 0.13% between the ages of 75 and 88 years. The reduction in rCBF in the hippocampus rose from 0.14% between the ages of 40 and 75 years to 0.33% between the ages of 75 and 88 years. The mean rCBF in all 33 individuals showed no sex-related differences.
采用配备高分辨率准直器的单光子发射断层扫描（SPET）γ相机系统，使用[99Tc（m）]-d，l-六甲基丙烯胺肟（HMPAO）对33名三个年龄组的正常个体进行脑血流量（CBF）的年龄相关性变化研究，这三个年龄组分别为：40岁（n = 11）、75岁（n = 9）和88岁（n = 13）。给予标准活度为1000 MBq的[99Tc（m）]-d，l-HMPAO。在28个灰质和白质区域对局部脑血流量（rCBF）（相对于小脑计数）进行定量分析。40岁组所有区域的平均rCBF为0.80（95%置信区间[CI] 0.77 - 0.83），75岁组为0.77（0.74 - 0.80），88岁组为0.76（0.73 - 0.78）。75岁和88岁组海马体、角回和扣带回以及额叶联合皮质和运动皮质的rCBF比中年受试者低5 - 10%（P < 0.05）。40岁至75岁之间rCBF的年降低率为0.10%，75岁至88岁之间为0.13%。海马体rCBF的降低率从40岁至75岁之间的0.14%上升至75岁至88岁之间的0.33%。所有33名个体的平均rCBF未显示出与性别相关的差异。
