Zhang L, Murata Y, Ishida R, Saitoh Y, Mizusawa H, Shibuya H
Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
Nucl Med Commun. 2001 Jul;22(7):767-72. doi: 10.1097/00006231-200107000-00007.
The purpose of this study was to evaluate the usefulness of brain perfusion single photon emission computed tomography (SPET) to differentiate between progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Twelve patients with PSP and 12 with CBD were examined by brain perfusion SPET using 99Tc(m)-ethyl cysteinate dimer (99Tc(m)-ECD). The regions of interest (ROIs) were five cortical regions, the basal ganglia, the thalamus, the cerebellar cortex and the brain stem. The mean regional cerebral blood flow (CBF) and the mean right/left asymmetry index in each ROI were calculated. The asymmetry index of the regional CBF was significantly higher in CBD patients compared with PSP patients in all of the cortical regions and in the basal ganglia. The greatest differences in asymmetry were in the parietal cortex (P<0.001), high frontal cortex (P<0.001), frontal cortex (P<0.005), temporal cortex (P<0.01) and basal ganglia (P<0.01). Significant asymmetry was also detected in the occipital cortex (P < 0.05). No significant difference in asymmetry was found in the thalamus or the cerebellum. There were no significant differences between the two groups in any of the regional CBF values. In conclusion, brain perfusion SPET with 99Tc(m)-ECD is useful in detecting the significantly higher perfusion asymmetry in CBD patients compared with PSP patients in all cortical regions and in the basal ganglia. SPET may be a useful tool for differentiating between PSP and CBD.
本研究的目的是评估脑灌注单光子发射计算机断层扫描（SPET）在区分进行性核上性麻痹（PSP）和皮质基底节变性（CBD）方面的效用。使用99锝（m）-乙半胱氨酸二聚体（99Tc（m）-ECD）通过脑灌注SPET对12例PSP患者和12例CBD患者进行了检查。感兴趣区域（ROI）为五个皮质区域、基底节、丘脑、小脑皮质和脑干。计算每个ROI中的平均局部脑血流量（CBF）和平均右/左不对称指数。在所有皮质区域和基底节中，CBD患者的局部CBF不对称指数显著高于PSP患者。不对称性差异最大的是顶叶皮质（P<0.001）、额上回皮质（P<0.001）、额叶皮质（P<0.005）、颞叶皮质（P<0.01）和基底节（P<0.01）。枕叶皮质也检测到显著不对称（P<0.05）。丘脑或小脑中未发现不对称性的显著差异。两组之间在任何局部CBF值上均无显著差异。总之，使用99Tc（m）-ECD的脑灌注SPET有助于检测出CBD患者与PSP患者相比在所有皮质区域和基底节中显著更高的灌注不对称性。SPET可能是区分PSP和CBD的有用工具。
