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实验性胰腺炎中甲状旁腺激素分泌增加与低钙血症:甲状腺完整的必要性。

Increased parathyroid hormone secretion and hypocalcemia in experimental pancreatitis: necessity for an intact thyroid gland.

作者信息

Norberg H P, DeRoos J, Kaplan E L

出版信息

Surgery. 1975 Jun;77(6):773-9.

PMID:1145441
Abstract

Elevated concentrations of serum parathyroid hormone and hypocalcemia occur following the induction of experimental pancreatitis in the pig, but only when the thyroid gland is present. Prior thyroidectomy completely eliminates these changes. Serum magnesium concentrations remained normal throughout the experiments despite the occurrence of hypocalcemia. These data support the hypothesis that calcitonin or another thyroid-related substance plays a role in the mechanism of the hypocalcemia which accompanies experimental pancreatitis in the pig.

摘要

在猪身上诱导实验性胰腺炎后会出现血清甲状旁腺激素浓度升高和低钙血症,但仅在甲状腺存在时才会出现。事先进行甲状腺切除可完全消除这些变化。尽管出现了低钙血症,但在整个实验过程中血清镁浓度仍保持正常。这些数据支持这样一种假说,即降钙素或另一种与甲状腺相关的物质在猪实验性胰腺炎伴发的低钙血症机制中起作用。

相似文献

1
Increased parathyroid hormone secretion and hypocalcemia in experimental pancreatitis: necessity for an intact thyroid gland.实验性胰腺炎中甲状旁腺激素分泌增加与低钙血症:甲状腺完整的必要性。
Surgery. 1975 Jun;77(6):773-9.
2
Effect of thyroid and parathyroid on hypocalcemia occurring after a magnesium load.甲状腺和甲状旁腺对镁负荷后发生的低钙血症的影响。
Endocrinology. 1968 Dec;83(6):1285-92. doi: 10.1210/endo-83-6-1285.
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Inadequate parathyroid response in acute pancreatitis.急性胰腺炎时甲状旁腺反应不足。
N Engl J Med. 1976 Mar 4;294(10):512-6. doi: 10.1056/NEJM197603042941002.
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Familial pseudohypoparathyroidism. Role of parathyroid hormone and thyrocalcitonin.家族性假性甲状旁腺功能减退症。甲状旁腺激素和甲状腺降钙素的作用。
N Engl J Med. 1968 Nov 28;279(22):1179-84. doi: 10.1056/NEJM196811282792201.
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Pathogenesis of hypocalcemia in magnesium depletion. Normal end-organ responsiveness to parathyroid hormone.镁缺乏时低钙血症的发病机制。终末器官对甲状旁腺激素的正常反应性。
J Clin Invest. 1971 Dec;50(12):2668-78. doi: 10.1172/JCI106768.
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Response of calcitonin cells, parathyroid, and serum electrolytes during glucagon-induced hypocalcemia in the mongoose, Herpestes edwardsi (Geoffroy).爱德华氏獴(赫氏獴,Geoffroy)在胰高血糖素诱导的低钙血症期间降钙素细胞、甲状旁腺及血清电解质的反应
Gen Comp Endocrinol. 1979 Apr;37(4):541-5. doi: 10.1016/0016-6480(79)90036-4.
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Role of the thyroid gland during glucagon-induced hypocalcemia in the dog.甲状腺在犬胰高血糖素诱导的低钙血症中的作用。
Am J Physiol. 1969 Apr;216(4):939-45. doi: 10.1152/ajplegacy.1969.216.4.939.
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[Parathyroid hormone (PTH) and calcitonin].[甲状旁腺激素(PTH)与降钙素]
Nihon Rinsho. 1971 Jul;29(7):1724-33.
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[Influence of hyper- and hypocalcemia on gastric secretion in rats].[高钙血症和低钙血症对大鼠胃分泌的影响]
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Pathogenesis of hypocalcemia in primary hypomagnesemia: normal end-organ responsiveness to parathyroid hormone, impaired parathyroid gland function.原发性低镁血症中低钙血症的发病机制:终末器官对甲状旁腺激素反应正常,甲状旁腺功能受损。
J Clin Invest. 1973 Jan;52(1):153-60. doi: 10.1172/JCI107159.

引用本文的文献

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Overview of exocrine pancreatic pathobiology.外分泌胰腺病理生物学概述。
Toxicol Pathol. 2014 Jan;42(1):207-16. doi: 10.1177/0192623313509907. Epub 2013 Nov 3.
2
Hypocalcemia in experimental pancreatitis occurs independently of changes in serum nonesterified fatty acid levels.实验性胰腺炎中的低钙血症独立于血清非酯化脂肪酸水平的变化而发生。
Int J Pancreatol. 1990 Jun;6(4):249-62. doi: 10.1007/BF02924404.