Patel A J, Lazdunski M, Honoré E
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560, Valbonne, France.
Curr Opin Cell Biol. 2001 Aug;13(4):422-8. doi: 10.1016/s0955-0674(00)00231-3.
The two pore domain K(+) channels TREK and TRAAK are opened by membrane stretch. The activating mechanical force comes from the bilayer membrane and is independent of the cytoskeleton. Emerging work shows that mechano-gated TREK and TRAAK are opened by various lipids, including long chain polyunsaturated anionic fatty acids and neutral cone-shaped lysophospholipids. TREK-1 shares the properties of the Aplysia neuronal S channel, a presynaptic background K(+) channel involved in behavioral sensitization, a simple form of learning.
双孔结构域钾通道TREK和TRAAK可被膜拉伸激活。激活的机械力来自双分子层膜，且独立于细胞骨架。最新研究表明，机械门控的TREK和TRAAK可被多种脂质激活，包括长链多不饱和阴离子脂肪酸和中性锥形溶血磷脂。TREK-1具有海兔神经元S通道的特性，该通道是一种参与行为敏感化（一种简单学习形式）的突触前背景钾通道。
