A novel method for the preparation of amino-substituted hypocrellin B.
作者信息
Xu S, Chen S, Zhang M, Shen T
机构信息
Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, 100080, Beijing, China.
出版信息
Bioorg Med Chem Lett. 2001 Aug 6;11(15):2045-7. doi: 10.1016/s0960-894x(01)00360-2.
Abstract
A series of amino-substituted hypocrellins derived from hypocrellin B (HB) were synthesized by a novel mild method, in which the peri-hydroxylated perylenequinone structure of hypocrellin was preserved by the reaction of HB with an amine. The red absorption of the resulting products was significantly enhanced relative to the parent hypocrellins, which will significantly improve its photodynamic therapy effectiveness.
摘要
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