具有改善红吸收和活性氧生成特性的竹红菌素衍生物。
Hypocrellin derivative with improvements of red absorption and active oxygen species generation.
作者信息
Xu Shangjie, Chen Shen, Zhang Manhua, Shen Tao
机构信息
Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, China.
出版信息
Bioorg Med Chem Lett. 2004 Mar 22;14(6):1499-501. doi: 10.1016/j.bmcl.2004.01.003.
PMID:15006390
Abstract
A novel diamino-substituted hypocrellin derived from hypocrellin B (HB) was synthesized by a mild method. The red absorption of the resulting product was significantly enhanced relative to the parent hypocrellins and any other hypocrellin derivatives, and the active oxygen species generating abilities were enhanced distinctly, which will remarkably improve its photodynamic therapy effectiveness.
摘要
通过一种温和的方法合成了一种源自竹红菌素B（HB）的新型二氨基取代竹红菌素。相对于母体竹红菌素和任何其他竹红菌素衍生物，所得产物的红色吸收显著增强，并且活性氧生成能力明显提高，这将显著提高其光动力治疗效果。
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