Yang Y L, Lo H J
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, ROC.
J Microbiol Immunol Infect. 2001 Jun;34(2):79-86.
During the past decade, yeast infections have had an important role in nosocomial infections due to alterations in the immune status of patients. Coincidentally with the increased usage of antifungal agents, the number of reports of drug resistance has increased, which highlights the need for understanding the molecular mechanisms of antifungal agent resistance. This review describes the mechanisms of action of antifungal agents, cellular factors contributing to drug resistance, the known molecular mechanisms of drug resistance, and proposed but unproved molecular mechanisms of drug resistance. This review also proposes possible strategies for preventing drug resistance.
在过去十年中，由于患者免疫状态的改变，酵母菌感染在医院感染中发挥了重要作用。与抗真菌药物使用增加同时发生的是，耐药性报告的数量也增加了，这凸显了了解抗真菌药物耐药分子机制的必要性。这篇综述描述了抗真菌药物的作用机制、导致耐药性的细胞因素、已知的耐药分子机制以及提出但未经证实的耐药分子机制。这篇综述还提出了预防耐药性的可能策略。
