Nygren J, Thorell A, Ljungqvist O
Centre of Gastrointestinal Disease, Karolinska Institutet at Ersta Hospital and Huddinge University Hospital, Stockholm, Sweden.
Curr Opin Clin Nutr Metab Care. 2001 Jul;4(4):255-9. doi: 10.1097/00075197-200107000-00002.
Insulin resistance is a central feature of the metabolic response after elective surgery as well as other trauma, and has been shown to be a predictor of the length of stay after surgery. Carbohydrate treatment instead of overnight fasting before surgery has been shown to reduce postoperative insulin resistance and to reduce hospital stay approximately 20% after elective surgery. For potential use as a clinical routine before surgery, a carbohydrate-rich drink was developed. Gastric emptying of a 50 g oral carbohydrate load using this drink is complete within 90 min after intake. Oral carbohydrate loading before surgery has confirmed previous data, using glucose and insulin infusions, that postoperative insulin resistance is reduced compared with overnight fasted patients before surgery, and this is associated with improved well-being before and after surgery.
胰岛素抵抗是择期手术以及其他创伤后代谢反应的核心特征，并且已被证明是术后住院时间的一个预测指标。与术前禁食过夜相比，术前给予碳水化合物治疗已被证明可降低术后胰岛素抵抗，并使择期手术后的住院时间缩短约20%。为了有可能作为术前临床常规使用，研发了一种富含碳水化合物的饮料。摄入这种饮料后，50克口服碳水化合物负荷在90分钟内即可完全从胃排空。术前口服碳水化合物负荷已证实了先前使用葡萄糖和胰岛素输注的数据，即与术前禁食过夜的患者相比，术后胰岛素抵抗有所降低，并且这与手术前后的良好状态改善相关。
