白细胞介素-6缺乏对小鼠牙髓暴露后根尖周病变形成的影响。
Effect of interleukin-6 deficiency on the formation of periapical lesions after pulp exposure in mice.
作者信息
Huang G T, Do M, Wingard M, Park J S, Chugal N
机构信息
Division of Associated Clinical Specialties, Section of Endodontics, UCLA School of Dentistry, Los Angeles, CA 90095-1668, USA.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Jul;92(1):83-8. doi: 10.1067/moe.2001.115025.
OBJECTIVE
The multifunctional cytokine interleukin-6 (IL-6) has actions on multiple cell types, including promotion of the development of immune cells and osteoclasts. Periapical inflammation as the result of root canal infection is characterized by the accumulation of inflammatory cells and bone resorption. The effect of IL-6 on periapical lesion formation after pulpal infection is unknown. We sought to determine whether deletion of IL-6 affects periapical lesion formation after pulp exposure.
METHODS
Molar pulps of homozygous IL-6 knock-out mice (IL-6(-/-), strain B6, 129-Il6tm1Koe ) and wild-type mice (IL-6(+/+)) were exposed, and the mice were killed at 1, 2, 3, 5, and 8 weeks after the exposure. Mouse jaws were decalcified and prepared for histologic examination of periapical lesions.
RESULTS
The IL-6(-/-) mice developed larger periapical lesions more rapidly than did the IL-6(+/+) mice.
CONCLUSIONS
IL-6 deletion promoted periapical lesion development.
目的
多功能细胞因子白细胞介素-6（IL-6）对多种细胞类型有作用，包括促进免疫细胞和破骨细胞的发育。根管感染导致的根尖周炎的特征是炎症细胞积聚和骨吸收。IL-6对牙髓感染后根尖周病变形成的影响尚不清楚。我们试图确定IL-6的缺失是否会影响牙髓暴露后根尖周病变的形成。
方法
将纯合IL-6基因敲除小鼠（IL-6(-/-)，B6、129-Il6tm1Koe品系）和野生型小鼠（IL-6(+/+)）的磨牙牙髓暴露，在暴露后1、2、3、5和8周处死小鼠。将小鼠颌骨脱钙并准备进行根尖周病变的组织学检查。
结果
IL-6(-/-)小鼠比IL-6(+/+)小鼠更快地形成更大的根尖周病变。
结论
IL-6缺失促进了根尖周病变的发展。
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