Kraft M, Ahluwahlia S, Angulo J A
Department of Biological Sciences, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10021, USA.
Ann N Y Acad Sci. 2001 Jun;937:132-9. doi: 10.1111/j.1749-6632.2001.tb03562.x.
Systemic exposure to neurokinin-1 receptor antagonists CP099994 or LY306740 prior to cocaine administration (10 mg/kg i.p.) blocks acute, cocaine-induced horizontal locomotion. CP099994 (30 mg/kg) was delivered i.p. 30 minutes before cocaine exposure, and LY306740 (5 mg/kg) was delivered continuously by osmotic minipump for 12-14 hours before cocaine administration. These results suggest that endogenous substance P acting via neurokinin-1 receptors is necessary for the expression of acute cocaine-induced hyperactivity.
在给予可卡因（10毫克/千克，腹腔注射）之前，全身性暴露于神经激肽-1受体拮抗剂CP099994或LY306740可阻断急性可卡因诱导的水平运动。CP099994（30毫克/千克）在接触可卡因前30分钟腹腔注射，LY306740（5毫克/千克）在给予可卡因前通过渗透微型泵连续给药12 - 14小时。这些结果表明，内源性P物质通过神经激肽-1受体起作用对于急性可卡因诱导的多动表达是必要的。
