Wen P, Li Y
School of Informatics and Engineering, University of SA, GPO Box 2100, Adelaide 5001, Australia.
Australas Phys Eng Sci Med. 2001 Mar;24(1):31-6. doi: 10.1007/BF03178283.
Most of the human head models used in dipole localisation research, which have been reported in the literature to date, assume a simplified cranial structure wherein the head is modelled as a set of distinct homogenous tissue compartments. The inherent inhomogeneity of the tissues has so far been ignored in these models due to the difficulties involved in obtaining the conductivity characteristics with sufficiently high enough spatial resolution throughout the head. A technique for developing an inhomogeneous head model based on the generation of pseudo-conductivity values from the existing but sparse conductivity values is proposed in this paper. Comparative studies are conducted on different model structures and different mechanisms for generating the pseudo conductivities. An evaluation of the results of these studies as reported in this paper, shows that contrary to current simplifying assumptions, tissue inhomogeneity has a major influence on the computation of electrical potential distributions in the head.
迄今为止，文献中报道的大多数用于偶极子定位研究的人体头部模型，都假定了一种简化的颅骨结构，即将头部建模为一组不同的均匀组织隔室。由于在整个头部以足够高的空间分辨率获取电导率特性存在困难，这些模型至今一直忽略了组织固有的不均匀性。本文提出了一种基于从现有的但稀疏的电导率值生成伪电导率值来开发非均匀头部模型的技术。对不同的模型结构和生成伪电导率的不同机制进行了比较研究。本文所报道的这些研究结果的评估表明，与当前的简化假设相反，组织不均匀性对头部电势分布的计算有重大影响。
