Shishkina L N, Kushireva E V, Smotriaeva M A
Emanuel Institute of Biochemical Physics, Russian Academy of Science, Moscow, 117977 Russia.
Radiats Biol Radioecol. 2001 May-Jun;41(3):301-6.
The effect of surfactant Tween 80 on the intensity of lipid peroxidation (LPO), the antioxidant status of liver and the DNA content in blood plasma of mice was studied. The surfactant was administered in a dose of 30 mg/kg before of after exposure of animals to X-rays (a dose of 16 cGy). It was found that the combined effect of Tween 80 and the low dose of X-rays caused disturbances in LPO regulatory system. Manifestation of the disturbances depended on the time interval after exposure, the fact whether Tween 80 was administered before or after irradiation, the examined tissue and the parameter studied. The administration of Tween 80 after irradiation intensified the effect of X-rays in more extent than its administration before irradiation.
研究了表面活性剂吐温80对小鼠脂质过氧化（LPO）强度、肝脏抗氧化状态及血浆DNA含量的影响。在动物接受X射线照射（剂量为16 cGy）之前或之后，以30 mg/kg的剂量给予表面活性剂。结果发现，吐温80与低剂量X射线的联合作用导致LPO调节系统紊乱。紊乱的表现取决于照射后的时间间隔、吐温80是在照射前还是照射后给予、所检查的组织以及所研究的参数。照射后给予吐温80比照射前给予更能增强X射线的作用。
