Barman S M, Orer H S, Gebber G L
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA.
Ann N Y Acad Sci. 2001 Jun;940:270-85. doi: 10.1111/j.1749-6632.2001.tb03683.x.
Data from experiments with single neuron recordings as well as central microinjections of N-methyl-D-aspartate (NMDA) and non-NMDA excitatory amino receptor antagonists that have led to a model of central sympathetic pathways that includes synaptic relays in the medullary lateral tegmental field (LTF) of the cat are summarized. Evidence is presented that (1) the LTF contains a population of tonically active sympathoexcitatory neurons that drive rostral ventrolateral medullary neurons, (2) blockade of non-NMDA receptors in the LTF significantly reduces basal levels of sympathetic nerve discharge (SND) and mean arterial pressure in baroreceptor-denervated cats, and (3) blockade of NMDA-mediated neurotransmission in the LTF prevents baroreceptor reflex control of SND. Thus, LTF neurons play an important role in the generation and baroreceptor reflex control of SND in the cat.
总结了来自单神经元记录实验的数据，以及向猫的延髓外侧被盖区（LTF）进行N-甲基-D-天冬氨酸（NMDA）和非NMDA兴奋性氨基酸受体拮抗剂的中枢微注射实验的数据，这些实验得出了一个中枢交感神经通路模型。有证据表明：（1）LTF包含一群持续活动的交感兴奋神经元，这些神经元驱动延髓头端腹外侧神经元；（2）在LTF中阻断非NMDA受体可显著降低压力感受器去神经猫的交感神经放电（SND）基础水平和平均动脉压；（3）在LTF中阻断NMDA介导的神经传递可阻止压力感受器对SND的反射控制。因此，LTF神经元在猫的SND产生和压力感受器反射控制中起重要作用。
