Bell G M, Schnitzer T J
Abgenix, Inc., Fremont, California 94555, USA.
Clin Geriatr Med. 2001 Aug;17(3):489-502, vi. doi: 10.1016/s0749-0690(05)70082-3.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed therapies for acute and chronic pain in the elderly. NSAIDs are effective in treating many disorders, but their use often is limited by toxicities, especially gastrointestinal and renal toxicity. COX-2 inhibitors are a major therapeutic advance, providing the analgesic and anti-inflammatory activity of NSAIDs, with a significant improvement in gastrointestinal safety. These new agents may be ideal therapies for older patients at risk for NSAID-related gastrointestinal toxicity.
非甾体抗炎药（NSAIDs）是老年人急慢性疼痛最常用的处方治疗药物之一。NSAIDs对多种病症有效，但其使用常因毒性而受限，尤其是胃肠道和肾脏毒性。COX-2抑制剂是一项重大治疗进展，具有NSAIDs的镇痛和抗炎活性，胃肠道安全性显著提高。这些新药可能是有NSAID相关胃肠道毒性风险的老年患者的理想治疗药物。
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