de Jong J C, Smit Sibinga C T, Wildevuur C R
Trans Am Soc Artif Intern Organs. 1975;21:40-8.
In summary, in contrast to a blood-membrane interphase system (artificial kidney), the use of a blood-gas interphase system (bubble oxygenator), even at a low flow rate of 400 ml/min, leads to severe changes in platelet function and number, to a temporary delay in fibrin formation and to a prolonged bleeding time. A definite bleeding tendency expresses the disturbance in hemostatic balance, as predominantly effected by the changes in platelet function. Hemolysis is apparently a minor symptom, and does not express the gravity of this damaging situation.
总之，与血膜界面系统（人工肾）不同，使用血气界面系统（鼓泡式氧合器），即使在400毫升/分钟的低流量下，也会导致血小板功能和数量发生严重变化，使纤维蛋白形成暂时延迟，并使出血时间延长。明确的出血倾向表明止血平衡受到干扰，这主要是由血小板功能的变化引起的。溶血显然是一个次要症状，并未体现出这种损伤情况的严重性。
