通过完全植入式泵持续输注对犬进行慢性肝素抗凝。
Chronic heparin anticoagulant in dogs by continuous infusion with a totally implantable pump.
作者信息
Rhode T D, Blachshear P J, Varco R L, Buchwald H
出版信息
Trans Am Soc Artif Intern Organs. 1975;21:510-5.
The ability of our implantable pump to provide continuous long-term drug infusion in abulatory animals has been demonstrated. Chronic heparinization has been achieved in the dog for 6 mos. Anticipated complications, hemorrhage and osteoporosis occurred, but not to a prohibitive degree. The successful performance of the pump in these animal studies has led us to plan a clinical trial using the pump for heparin anticoagulation in patients and to investigate employment of the pump in cancer chemotherapy, insulin for the treatment of diabetes, and other purposes.
我们的植入式泵在活动动物体内提供持续长期药物输注的能力已得到证实。在狗身上已实现了6个月的慢性肝素化。出现了预期的并发症，如出血和骨质疏松，但程度并不严重。该泵在这些动物研究中的成功表现促使我们计划进行一项临床试验，在患者中使用该泵进行肝素抗凝，并研究该泵在癌症化疗、糖尿病治疗用胰岛素及其他用途中的应用。
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