Ritschel W A, Brady M E
Arzneimittelforschung. 1979;29(12):1891-4.
A pharmacokinetic approach was developed for the determination of an individualized heparin dosage regimen for an i.v. constant infusion rate. The rabbit was chosen as the animal model. From a test dose given i.v. the individual rate constant for loss of anticoagulant response was determined by measuring the whole blood activated clotting time. After selection of a desired clotting time to be maintained, the loading dose and infusion rate or heparin concentration at set infusion rate were calculated. In the three infusion studies used to illustrate this method, less than a 4% average deviation resulted between the actual clotting times and the desired clotting times.
已开发出一种药代动力学方法，用于确定静脉恒速输注时个体化肝素给药方案。选用兔子作为动物模型。通过静脉给予试验剂量，测量全血活化凝血时间来确定抗凝反应消失的个体速率常数。在选择要维持的期望凝血时间后，计算负荷剂量和输注速率或设定输注速率下的肝素浓度。在用于说明该方法的三项输注研究中，实际凝血时间与期望凝血时间之间的平均偏差小于4%。
