由骨形态发生蛋白（BMP）形态发生梯度对Dlx基因表达的差异性调控。

Differential regulation of Dlx gene expression by a BMP morphogenetic gradient.

作者信息

Luo T, Matsuo-Takasaki M, Lim J H, Sargent T D

机构信息

Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2790, USA.

出版信息

Int J Dev Biol. 2001 Jun;45(4):681-4.

PMID:11461005

Abstract

Three members of the vertebrate Distal-less gene family, Dlx3, 5 and 6, are transcribed in early gastrula embryos of Xenopus laevis. This expression is confined to ectoderm and is excluded from the presumptive neural plate region. Expression of all three genes is dependent upon BMP signaling, with significant differences in how the three genes respond to the BMP antagonist chordin. This correlates with the different expression domain boundaries in vivo for Dlx3 compared to Dlx5 and 6, suggesting that BMP signal attenuation could be the primary factor in determining these different patterns in the gastrula ectoderm.

摘要

脊椎动物远端缺失基因家族的三个成员Dlx3、5和6在非洲爪蟾的原肠胚早期胚胎中表达。这种表达局限于外胚层，且被排除在预定神经板区域之外。这三个基因的表达都依赖于骨形态发生蛋白（BMP）信号传导，在这三个基因对BMP拮抗剂脊索蛋白的反应方式上存在显著差异。这与Dlx3在体内与Dlx5和6不同的表达域边界相关，表明BMP信号衰减可能是决定原肠胚外胚层中这些不同模式的主要因素。