Morgan Richard, Sohal Jastinder, Paleja Mita, Pettengell Ruth
Department of Basic Medical Sciences, St. George's Hospital Medical School, London, UK.
Int J Dev Biol. 2004 Sep;48(7):623-7. doi: 10.1387/ijdb.041887rm.
Development of the vertebrate eye is dependent on multiple tissue interactions and distinct sets of transcription factors and signalling molecules. The latter are thought to be FGF8 and BMP4, proteins secreted from the neural plate to induce lens formation in the overlying ectoderm. Here we show that the Pbx transcription factor plays a crucial role in this process, as it is required for FGF8 expression in the neural plate and is thus part of the complex hierarchy of genes involved in lens induction.
脊椎动物眼睛的发育依赖于多种组织间的相互作用以及不同组的转录因子和信号分子。后者被认为是FGF8和BMP4，它们是从神经板分泌出来的蛋白质，可诱导上覆外胚层形成晶状体。我们在此表明，Pbx转录因子在这一过程中起着关键作用，因为它是神经板中FGF8表达所必需的，因此是参与晶状体诱导的复杂基因层级的一部分。
