p21（WAF1/CIP1）和p53蛋白在胃癌中的表达：其与细胞增殖活性及预后的关系

Expression of p21(WAF1/CIP1) and p53 proteins in gastric carcinoma: its relationships with cell proliferation activity and prognosis.

作者信息

Liu X P, Tsushimi K, Tsushimi M, Kawauchi S, Oga A, Furuya T, Sasaki K

机构信息

Department of Pathology, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube-shi, Yamaguchi 755-8505, Japan.

出版信息

Cancer Lett. 2001 Sep 20;170(2):183-9. doi: 10.1016/s0304-3835(01)00589-4.

DOI:10.1016/s0304-3835(01)00589-4

PMID:11463497

Abstract

The expressions of p21(WAF1/CIP1), p53 proteins, and Ki-67 antigen were investigated immunohistochemically in 190 primary gastric carcinomas. Of the 190 tumors, 40.5% positively expressed p21(WAF1/CIP1) and 42.1% positively expressed p53. The expression of p21(WAF1/CIP1) was significantly associated with clinicopathological factors including gender, tumor size, status of lymph node, and clinicopathological stage (P<0.05 for all), but p21(WAF1/CIP1) expression showed no clear correlation with Ki-67 labeling index. The mean Ki-67 labeling index was significantly higher in p53-positive cases than p53-negative cases (P<0.0001). However, among the clinicopathological factors examined, expression of p53 correlated only with age. Univariate and multivariate survival analyses revealed that clinicopathological stage (P<0.001) and expression status of p21(WAF1/CIP1) (P<0.05) were independent prognostic factors. Neither the expression status of p53 nor the Ki-67 labeling index, however, influenced the prognosis of patients with gastric cancer.

摘要

采用免疫组织化学方法对190例原发性胃癌组织中p21（WAF1/CIP1）、p53蛋白及Ki-67抗原的表达情况进行研究。在这190例肿瘤中，40.5%呈p21（WAF1/CIP1）阳性表达，42.1%呈p53阳性表达。p21（WAF1/CIP1）的表达与包括性别、肿瘤大小、淋巴结状态及临床病理分期在内的临床病理因素显著相关（均P<0.05），但p21（WAF1/CIP1）表达与Ki-67标记指数无明显相关性。p53阳性病例的平均Ki-67标记指数显著高于p53阴性病例（P<0.0001）。然而，在所检测的临床病理因素中，p53的表达仅与年龄相关。单因素和多因素生存分析显示，临床病理分期（P<0.001）及p21（WAF1/CIP1）的表达状态（P<0.05）是独立的预后因素。然而，p53的表达状态及Ki-67标记指数均不影响胃癌患者的预后。