稽留流产中的经宫颈胚胎镜检查
Transcervical embryoscopy in missed abortion.
作者信息
Philipp T, Kalousek D K
机构信息
Ludwig Boltzman Institute of Gynecology and Obstetrics, Danube Hospital, Langobardenstrasse 122, 1220 Vienna, Austria.
出版信息
J Assist Reprod Genet. 2001 May;18(5):285-90. doi: 10.1023/a:1016666301481.
PURPOSE
The present study was conducted to determine the usefulness of transcervical embryoscopy in diagnosing localized and systemic defects in embryonic morphogenesis of missed abortions.
METHODS
The study population consisted of 24 women with the final diagnosis of missed abortion. Prior to the instrumental evacuation of the uterus a rigid hysteroscope was passed transcervically into the amniotic cavity to obtain a detailed view of the embryo. Karyotyping was attempted in all cases included in this study.
RESULTS
An embryo could be visualized in 19 cases. Ten embryos showed multiple developmental defects.
CONCLUSIONS
In cases of early failure of pregnancy, embryoscopy permits visualization of the embryo in utero, unaffected by the damage usually caused by its instrumental evacuation or spontaneous passage. This technique can be a helpful tool for pathologists and geneticists in enhancing their understanding of human embryonic malformations, but more importantly, it improves clinical care and follow-up, especially in cases of repeated abortions.
目的
本研究旨在确定经宫颈胚胎镜检查在诊断稽留流产胚胎形态发生中的局部和全身缺陷方面的实用性。
方法
研究对象为24例最终诊断为稽留流产的女性。在器械清宫术前，将硬性宫腔镜经宫颈插入羊膜腔以详细观察胚胎。本研究纳入的所有病例均尝试进行核型分析。
结果
19例可观察到胚胎。10个胚胎显示出多种发育缺陷。
结论
在妊娠早期失败的病例中，胚胎镜检查可在子宫内观察胚胎，不受器械清宫或自然排出通常造成的损伤影响。该技术可为病理学家和遗传学家增进对人类胚胎畸形的理解提供有用工具，但更重要的是，它改善了临床护理和随访，尤其是在反复流产的病例中。
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