Elmér M
Acta Physiol Scand. 1975 Feb;93(2):202-5. doi: 10.1111/j.1748-1716.1975.tb05810.x.
The pressure response of the rat urinary bladder to electrical stimulation of the pelvic nerve at a low stimulation frequency was found to be almost completely atropine resistant. However, the response to stimulation of the degenerating pelvic nerve 20-30 h after section of the nerve postganglionically using maximal stimulation frequency was totally abolished by atropine or the parasympatholytic agent Hoechst 9980. The responses were not affected by hexamethonium or dihydroergotamine, but were potentiated by eserine. The non-adrenergic portion of the bladder response to stimulation of the degenerating hypogastric nerves was also abolished by atropine or Hoechst 9980. It is concluded that the transmitter activating the detrusor muscle at stimulation of the pelvic nerve or the non-adrenergic part of the hypogastric nerve probably is acetylcholine.
研究发现，在低刺激频率下，大鼠膀胱对盆神经电刺激的压力反应几乎完全不受阿托品影响。然而，在节后切断神经20 - 30小时后，使用最大刺激频率刺激退变的盆神经，其反应可被阿托品或抗副交感神经药物赫斯特9980完全消除。这些反应不受六甲铵或双氢麦角胺的影响，但被毒扁豆碱增强。膀胱对退变的腹下神经刺激的反应中，非肾上腺素能部分也可被阿托品或赫斯特9980消除。结论是，刺激盆神经或腹下神经的非肾上腺素能部分时，激活逼尿肌的递质可能是乙酰胆碱。
