Baldock R, Bard J, Brune R, Hill B, Kaufman M, Opstad K, Smith D, Stark M, Waterhouse A, Yang Y, Davidson D
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.
Brief Bioinform. 2001 May;2(2):159-69. doi: 10.1093/bib/2.2.159.
This paper provides a simple introduction to the reconstructions and data-handling tools stored on the Edinburgh Mouse Atlas CD, together with some of the ways in which the viewers and software can be used to understand mouse development and analyse data. The key aspect of the Mouse Atlas is that the underlying models are a complete representation of the histology, which has not been constrained to a particular interpretation. This means, for example, that the current anatomy domains can be further subdivided as required to any resolution up to the resolution of the models (2-7 microm). In the CD of the early embryos described here, virtually all tissues that can be usefully distinguished either by the histology or morphologically have been delineated.
本文简要介绍了存储在爱丁堡小鼠图谱光盘上的重建和数据处理工具,以及一些使用查看器和软件来理解小鼠发育和分析数据的方法。小鼠图谱的关键之处在于其基础模型是组织学的完整呈现,并未局限于特定的解释。例如,这意味着当前的解剖学区域可以根据需要进一步细分,直至达到模型的分辨率(2 - 7微米)。在此处描述的早期胚胎光盘中,几乎所有通过组织学或形态学能够有效区分的组织都已被描绘出来。