Hallberg D, Pernow B
Acta Physiol Scand. 1975 Feb;93(2):277-85. doi: 10.1111/j.1748-1716.1975.tb05816.x.
Using the electromagnetic flowmeter technique, the blood flow in the aorta, carotid, hepatic, superior mesenteric, renal and femoral arteries and portal vein was recorded during continuous i.v. infusion of synthetic Substance P (SP) in 8 dogs. Systemic and portal blood pressures were recorded. A significant decrease in mean arterial blood pressure was recorded at infusion of SP in the femoral vein at a rate of 2.5 ng x min-1 x kg b.w.-1 or higher. Portal venous blood pressure increased. A rapid increase in the carotid, hepatic, mesenteric and portal blood flow was obtained at infusion rates of 1.2 ng x min-1 x kg b.w.-1 or higher. The femoral artery responded with a late, transient increase in flow, with a return to the base level while the infusion was still in progress. The renal artery 0lood flow decreased slightly at low infusion rates and increased at higher. At SP infusions in the portal vein the infusion rate had to be increased to 20 ng x min-1 x kg b.w.-1 or higher before any general vascular reactions lere recorded, indicating that the liver has a high capacity for inactivating SP.
采用电磁流量计技术，在8只犬连续静脉输注合成P物质（SP）期间，记录主动脉、颈动脉、肝动脉、肠系膜上动脉、肾动脉、股动脉和门静脉的血流情况。记录体循环血压和门静脉血压。以2.5 ng·min⁻¹·kg体重⁻¹或更高的速率在股静脉输注SP时，平均动脉血压显著下降。门静脉血压升高。以1.2 ng·min⁻¹·kg体重⁻¹或更高的输注速率时，颈动脉、肝动脉、肠系膜动脉和门静脉血流迅速增加。股动脉血流出现延迟、短暂增加，在输注仍在进行时恢复至基线水平。低输注速率时肾动脉血流略有下降，高输注速率时则增加。在门静脉输注SP时，必须将输注速率提高到20 ng·min⁻¹·kg体重⁻¹或更高才能记录到任何全身性血管反应，这表明肝脏对SP的灭活能力很强。
