微管马达蛋白、磷酸化作用与神经丝的轴突运输

Microtubule motors, phosphorylation and axonal transport of neurofilaments.

作者信息

Shea T B

机构信息

Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts, Lowell, MA 01854, USA.

出版信息

J Neurocytol. 2000 Nov-Dec;29(11-12):873-87. doi: 10.1023/a:1010951626090.

DOI:10.1023/a:1010951626090

PMID:11466476

Abstract

The recent demonstration that the axonal transport motors kinesin and dynein participate in axonal transport of neurofilaments (NFs), and that the association of NFs with these motors is regulated by phosphorylation provides new insight into several aspects of axonal transport and NF biology. This review juxtaposes older and more recent findings on NF dynamics, and speculates on the organization of axonal NFs as suggested by real-time analyses of NF transport.

摘要

最近的研究表明，轴突运输马达驱动蛋白和动力蛋白参与神经丝（NFs）的轴突运输，并且神经丝与这些马达的结合受磷酸化调节，这为轴突运输和神经丝生物学的几个方面提供了新的见解。这篇综述将关于神经丝动力学的早期和最新发现并列在一起，并根据神经丝运输的实时分析结果推测轴突神经丝的组织方式。