Hashimoto T, Takahashi K, Goto M, Endo H, Kono T, Nishiyama H, Iimura F, Kuwashima S, Sawada H, Saiki N, Yamato M, Fujioka M
Department of Radiology, Dokkyo University School of Medicine, Tochigi, Japan.
Radiat Med. 2001 May-Jun;19(3):169-72.
99mTc-tetrofosmin was developed as a myocardial perfusion imaging agent and can also be used to depict tumors. We have experienced five cases of malignant thymoma delineated on 99mTc-tetrofosmin SPECT. In one case significant activity was clearly detected in the primary tumor and metastatic lesions. In quantitative analysis, similar 99mTc-tetrofosmin and 201Tl-chloride uptake ratios were obtained (1.95+/-0.57 versus 2.27+/-0.85, respectively; n.s.). The ability of 99mTc-tetrofosmin to detect malignant thymoma was comparable to that of 201Tl-chloride. Therefore, 99mTc-tetrofosmin might be a useful tracer for the detection of malignant thymoma, although more studies will be required to evaluate its diagnostic accuracy.
99m锝-替曲膦被开发用作心肌灌注显像剂，也可用于描绘肿瘤。我们遇到过5例在99m锝-替曲膦单光子发射计算机断层扫描（SPECT）上显示的恶性胸腺瘤。在1例病例中，在原发性肿瘤和转移灶中均清晰检测到明显的放射性活性。在定量分析中，99m锝-替曲膦和氯化铊摄取率相似（分别为1.95±0.57和2.27±0.85；无显著性差异）。99m锝-替曲膦检测恶性胸腺瘤的能力与氯化铊相当。因此，99m锝-替曲膦可能是检测恶性胸腺瘤的一种有用示踪剂，尽管需要更多研究来评估其诊断准确性。
