Tizabi Y, Getachew B, Davila-Garcia M, Taylor R E
Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA.
Alcohol Alcohol. 2001 Jul-Aug;36(4):318-22. doi: 10.1093/alcalc/36.4.318.
This study was designed to determine whether inherent alcohol preference is associated with differential expression of central nicotinic receptors. [(3)H]Cytisine and [(125)I]alpha-bungarotoxin binding-site, ligands selective for alpha4beta2 and alpha7 nicotinic receptor subtypes, respectively, were determined in various brain regions of alcohol-preferring (P) and non-preferring (NP) rats. Only the striatum of P rats had a reduction in the number of binding sites for both ligands, compared to NP rats. The data suggest a link between striatal nicotinic receptors and alcohol preference.
本研究旨在确定内在酒精偏好是否与中枢烟碱受体的差异表达有关。分别在嗜酒（P）和不嗜酒（NP）大鼠的不同脑区测定了[（3）H]金雀花碱和[（125）I]α-银环蛇毒素结合位点，这两种配体分别对α4β2和α7烟碱受体亚型具有选择性。与NP大鼠相比，只有P大鼠的纹状体中两种配体的结合位点数量减少。数据表明纹状体烟碱受体与酒精偏好之间存在联系。
