日本阿尔茨海默病患者中胱抑素C基因多态性与疾病无关联。
Lack of an association between cystatin C gene polymorphisms in Japanese patients with Alzheimer's disease.
作者信息
Maruyama H, Izumi Y, Oda M, Torii T, Morino H, Toji H, Sasaki K, Terasawa H, Nakamura S, Kawakami H
机构信息
Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
出版信息
Neurology. 2001 Jul 24;57(2):337-9. doi: 10.1212/wnl.57.2.337.
Associations between polymorphisms of the cystatin C gene (CST3) at 5' flanking region and exon 1 in Caucasian patients with late onset AD and exon 1 in a US study of late onset AD have been reported. Clinically diagnosed Japanese patients with AD and Japanese normal control subjects were assessed for the presence of polymorphisms of CST3. The authors could not confirm the previously reported association between CST3 polymorphisms and AD in Japan. Age had no effect on the CST3 genotype.
据报道，在白种人晚发性阿尔茨海默病（AD）患者中，胱抑素C基因（CST3）5'侧翼区域和外显子1的多态性之间存在关联，并且在美国一项关于晚发性AD的研究中，外显子1也存在这种关联。对临床诊断为AD的日本患者和日本正常对照受试者进行了CST3多态性检测。作者无法证实此前报道的日本人群中CST3多态性与AD之间的关联。年龄对CST3基因型没有影响。
Zotero 插件