Klastersky J, Hensgens C, Daneau D
Am J Med Sci. 1975 Mar-Apr;269(2):201-7. doi: 10.1097/00000441-197503000-00006.
Two groups of 38 patients have been treated for staphylococcal infection with either cephaloridine (4 gm daily) or gentamicin (320 mg daily) by the intramuscular route. The rate of favorable clinical response was higher among the patients who received cephaloridine (78.8 per cent) than among those who were treated with gentamicin (60.5 per cent). No death related to the infection occurred in the cephaloridine-treated patients. The mean peak and trough antibacterial activity reached in the serum of the patients after injection of the antibiotics was higher in patients receiving cephaloridine (1/64 and 1/16) than in those treated with gentamicin (1/16 and 1/4). Patients who failed to respond to therapy had often a low antibacterial activity of the serum. These studies suggest that the 1/8 level of bactericidal activity should be attained in the serum one hour after the administration of the antibiotics to allow optimal results in staphylococcal infections.
两组各38例葡萄球菌感染患者分别接受了肌肉注射头孢菌素（每日4克）或庆大霉素（每日320毫克）治疗。接受头孢菌素治疗的患者中临床疗效良好的比例（78.8%）高于接受庆大霉素治疗的患者（60.5%）。接受头孢菌素治疗的患者中未发生与感染相关的死亡。注射抗生素后，接受头孢菌素治疗的患者血清中达到的平均峰浓度和谷浓度抗菌活性（1/64和1/16）高于接受庆大霉素治疗的患者（1/16和1/4）。治疗无效的患者血清抗菌活性通常较低。这些研究表明，抗生素给药后1小时血清中杀菌活性应达到1/8水平，以使葡萄球菌感染获得最佳疗效。
