Ishiguro T
Am J Obstet Gynecol. 1975 Feb 15;121(4):539-41. doi: 10.1016/0002-9378(75)90088-5.
Serum alpha-fetoprotein (AFP) levels in patients with hydatidiform mole, choriocarcinoma, and twin pregnancy were studied by radioimmunoassay. Serum AFP was absent in seven of seven patients (100 per cent) with choriocarcinoma and 10 of 13 (76.9 per cent) with hydatidiform mole. However, low concentrations (below 8 ng. per milliliter) of AFP were detected in two patients (15.4 per cent) and 105 ng. per milliliter in one (7.7 per cent) with hydatidiform mole. In 10 of 14 patients (71.4 per cent) with twin pregnancy serum AFP levels were significantly above the normal range for single pregnancy and approximately twice as high as the average value in pregnancy. It was concluded from these findings that abnormal levels of serum AFP during pregnancy suggest the presence of various complications such as hydatidiform mole, choriocarcinoma, or twin pregnancy and that the determination of serum AFP is valuable for prenatal diagnosis. The origin and significance of elevated AFP in patients with hydatidiform mole are now being investigated.
采用放射免疫分析法对葡萄胎、绒毛膜癌和双胎妊娠患者的血清甲胎蛋白（AFP）水平进行了研究。7例绒毛膜癌患者（100%）和13例葡萄胎患者中的10例（76.9%）血清AFP呈阴性。然而，在2例葡萄胎患者（15.4%）中检测到低浓度（低于每毫升8纳克）的AFP，1例（7.7%）患者的AFP浓度为每毫升105纳克。14例双胎妊娠患者中有10例（71.4%）血清AFP水平显著高于单胎妊娠的正常范围，约为妊娠平均值的两倍。从这些发现得出的结论是，孕期血清AFP水平异常提示存在各种并发症，如葡萄胎、绒毛膜癌或双胎妊娠，并且血清AFP的测定对产前诊断有价值。目前正在研究葡萄胎患者AFP升高的来源和意义。
