Friedrich E, Keller E, Jaeger-Whitegiver E R, Joel E W, Schindler A E
Am J Obstet Gynecol. 1975 Jul 1;122(5):642-9. doi: 10.1016/0002-9378(75)90064-2.
This study was undertaken to investigate the effect of daily ingestion of 0.5 mg. of lynestrenol on some parameters of the hypothalamic-pituitary-ovarian axis. Daily plasma concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol-17-beta (estradiol; E2-17beta), and progesterone (P) were determined by specific radioimmunoassays during one control and one treatment cycle of seven normally ovulating women. One of the volunteers was followed throughout 84 days of treatment. The following changes were observed during medication: (1) the midcycle FSH/LH peak was abolished, with a trend toward reduced LH values during the second half of the treatment cycles; (2) progesterone was significantly, though variably, reduced whereas estradiol showed little difference between control and treatment cycles; (3) during prolonged treatment two difference cyclic response patterns were observed in the same individual. It is concluded that daily administration of 0.5 mg. of lynestrenol exerts a profound effect at the central level, which contributes to the satisfactory contraceptive efficacy of this compound. A hypothetic blockade of estradiol receptors at the pituitary and/or hypothalamic level is discussed.
本研究旨在探讨每日摄入0.5毫克炔雌醇对下丘脑-垂体-卵巢轴某些参数的影响。通过特异性放射免疫分析法，测定了7名正常排卵女性在一个对照周期和一个治疗周期内每日血浆中促卵泡激素（FSH）、促黄体生成素（LH）、雌二醇-17-β（雌二醇；E2-17β）和孕酮（P）的浓度。对其中一名志愿者进行了为期84天的治疗跟踪。用药期间观察到以下变化：（1） 周期中期的FSH/LH峰值消失，在治疗周期的后半期LH值有降低趋势；（2） 孕酮显著降低，尽管存在个体差异，而雌二醇在对照周期和治疗周期之间差异不大；（3） 在长期治疗期间，同一个体观察到两种不同的周期反应模式。得出的结论是，每日服用0.5毫克炔雌醇在中枢水平上产生深远影响，这有助于该化合物令人满意的避孕效果。文中讨论了垂体和/或下丘脑水平上雌二醇受体的假设性阻断。
