水负荷对沙漠鹌鹑肾小球和肾小管功能的影响。
Effects of water load on renal glomerular and tubular function in desert quail.
作者信息
Braun E J, Dantzler W H
出版信息
Am J Physiol. 1975 Jul;229(1):222-8. doi: 10.1152/ajplegacy.1975.229.1.222.
Effects of an acute intravenous water load on glomerular and tubular function were studied in the anesthetized desert quail Lophortyx gambelii. Total-kidney glomerular filtration rate (GFR) and single-nephron glomerular filtration rates (SNGFR) of reptilian-type and mammalian-type nephrons increased by more than 50% compared with the GFR and SNGFRs measured during a control mannitol diuresis. Despite the increase in GFR, urine flow rate was only 56% of that in control mannitol diuresis, free-water clearance (CH2o) remained at 1-2% of GFR, and the animals excreted only about 79% of the water load. More than 99% of the filtered sodium and 93% of the filtered water were reabsorbed during the water load. Possible reasons for the increased GFR and the failure to produce a dilute urine or excrete the water load are discussed.
在麻醉的沙漠鹌鹑（Lophortyx gambelii）中研究了急性静脉注射水负荷对肾小球和肾小管功能的影响。与在对照甘露醇利尿期间测得的肾小球滤过率（GFR）和单肾单位肾小球滤过率（SNGFR）相比，爬行动物型和哺乳动物型肾单位的全肾GFR和SNGFR增加了50%以上。尽管GFR增加，但尿流率仅为对照甘露醇利尿时的56%，自由水清除率（CH2o）仍保持在GFR的1%-2%，并且动物仅排出了约79%的水负荷。在水负荷期间，超过99%的滤过钠和93%的滤过水被重吸收。文中讨论了GFR增加以及未能产生稀释尿液或排出水负荷的可能原因。
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