种族和血糖控制是马来西亚糖尿病血脂异常的主要决定因素。

Ethnicity and glycaemic control are major determinants of diabetic dyslipidaemia in Malaysia.

作者信息

Ismail I S, Nazaimoon W, Mohamad W, Letchuman R, Singaraveloo M, Hew F L, Shuguna C, Khalid B A

机构信息

Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

出版信息

Diabet Med. 2001 Jun;18(6):501-8. doi: 10.1046/j.1464-5491.2001.00494.x.

DOI:10.1046/j.1464-5491.2001.00494.x

PMID:11472471

Abstract

AIMS

To define the prevalence of dyslipidaemia in young diabetic patients in Peninsular Malaysia and the contributory factors of dyslipidaemia in these subjects.

METHODS

This is a cross-sectional study involving 848 young diabetic patients from seven different centres, with representation from the three main ethnic groups. Clinical history and physical examination was done and blood taken for HbA1c, fasting glucose, total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol and triglycerides.

RESULTS

The overall lipids were suboptimal, worse in Type 2 diabetes mellitus (DM) patients compared with Type 1 DM patients. Of the Type 2 patients, 73.2% had total cholesterol > 5.20 mmol/l, 90.9% had LDL-cholesterol > 2.60 mmol/l, 52.6% had HDL-cholesterol < 1.15 mmol/l and 27.3% had serum triglycerides > 2.30 mmol/l. There were ethnic differences in the lipid levels with the Malays having the highest total cholesterol (mean 6.19 mmol/l), and the highest LDL-cholesterol (mean 4.16 mmol/l), while the Chinese had the highest HDL-cholesterol (geometric mean 1.24 mmol/l). Ethnicity was an important determinant of total, LDL- and HDL-cholesterol in Type 2 DM, and LDL- and HDL-cholesterol and triglycerides in Type 1 DM. Glycaemic control was an important determinant of total, LDL-cholesterol and triglycerides in both Type 1 and Type 2 DM. Waist-hip ratio (WHR) was an important determinant of HDL-cholesterol and triglycerides in both types of DM. Gender was an important determinant of HDL-cholesterol in Type 2 DM, but not in Type 1 DM. Socioeconomic factors and diabetes care facilities did not have any effect on the dyslipidaemia.

CONCLUSIONS

The prevalence of dyslipidaemia was high especially in Type 2 DM patients. Ethnicity, glycaemic control, WHR, and gender were important determinants of dyslipidaemia in young diabetic patients. Diabet. Med. 18, 501-508 (2001)

摘要

目的

确定马来西亚半岛年轻糖尿病患者血脂异常的患病率以及这些患者血脂异常的促成因素。

方法

这是一项横断面研究，涉及来自七个不同中心的848名年轻糖尿病患者，涵盖了三个主要种族群体。记录临床病史并进行体格检查，采集血液检测糖化血红蛋白、空腹血糖、总胆固醇、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）胆固醇以及甘油三酯。

结果

总体血脂情况欠佳，2型糖尿病（DM）患者比1型糖尿病患者更差。在2型患者中，73.2%的患者总胆固醇>5.20 mmol/L，90.9%的患者低密度脂蛋白胆固醇>2.60 mmol/L，52.6%的患者高密度脂蛋白胆固醇<1.15 mmol/L，27.3%的患者血清甘油三酯>2.30 mmol/L。血脂水平存在种族差异，马来人的总胆固醇最高（平均6.19 mmol/L），低密度脂蛋白胆固醇也最高（平均4.16 mmol/L），而华人的高密度脂蛋白胆固醇最高（几何平均数1.24 mmol/L）。种族是2型糖尿病患者总胆固醇、低密度脂蛋白和高密度脂蛋白胆固醇以及1型糖尿病患者低密度脂蛋白、高密度脂蛋白胆固醇和甘油三酯的重要决定因素。血糖控制是1型和2型糖尿病患者总胆固醇、低密度脂蛋白胆固醇和甘油三酯的重要决定因素。腰臀比（WHR）是两种类型糖尿病患者高密度脂蛋白胆固醇和甘油三酯的重要决定因素。性别是2型糖尿病患者高密度脂蛋白胆固醇的重要决定因素，但不是1型糖尿病患者的决定因素。社会经济因素和糖尿病护理设施对血脂异常没有任何影响。