Zülch A, Becker M B, Gruss P
Department of Molecular Cell Biology, Max-Planck-Institute of Biophysical Chemistry, Am Fassberg 11, 37075, Göttingen, Germany.
Mech Dev. 2001 Aug;106(1-2):159-62. doi: 10.1016/s0925-4773(01)00411-7.
Irx1 and Irx2 are members of the murine Iroquois homeobox (Irx) gene family. In this study, we describe the dynamic expression pattern of these genes during limb development with a focus on digit formation. We further present a comparative expression analysis with Gli genes (Gli1, Gli2, Gli3). Gli1, Gli2, and Gli3 were suggested for candidate regulators of the Irx genes. The expression was studied between E11.5 and E14.5 when the digits are being formed. Irx1 and Irx2 reproduce the developmental program of the digits in time and space and the Irx1 provides an early and excellent marker for this process. Our analysis also indicates that the expression of Irx1, Gli1 and Irx2, Gli2 are relative to each other. In contrast, Gli3 exhibits a different expression pattern.
Irx1和Irx2是小鼠Iroquois同源框（Irx）基因家族的成员。在本研究中，我们描述了这些基因在肢体发育过程中的动态表达模式，重点关注指（趾）形成。我们还对Gli基因（Gli1、Gli2、Gli3）进行了比较表达分析。Gli1、Gli2和Gli3被认为是Irx基因的候选调节因子。在E11.5至E14.5期间指（趾）正在形成时对表达进行了研究。Irx1和Irx2在时间和空间上重现了指（趾）的发育程序，并且Irx1为这一过程提供了一个早期且优良的标志物。我们的分析还表明，Irx1与Gli1以及Irx2与Gli2的表达相互关联。相比之下，Gli3表现出不同的表达模式。
