Drozdzowska B, Pluskiewicz W
Department of Pathomorphology, Silesian School of Medicine, Zabrze, Poland.
Bone. 2001 Jul;29(1):79-83. doi: 10.1016/s8756-3282(01)00472-0.
The aim of the study was to establish a relationship between mothers' and daughters' bone status. Forty-eight postmenopausal women and their 48 premenopausal daughters were evaluated. The analysis was made for the whole group and for two subgroups: 27 healthy mothers and their 27 daughters; and 21 fractured mothers and their 21 daughters. The subgroups were matched for age and years since menopause (YSM), and height, weight, and body mass index (BMI) did not differ significantly. Bone status was evaluated by ultrasound measurement at the heel using the Achilles system (Lunar, Madison, WI), which measures speed of sound (SOS [m/sec]) and broadband ultrasound attenuation (BUA [dB/MHz]). The Achilles software also calculates a stiffness index (SI [%]). Ultrasound values for BUA, SOS, stiffness index, and Z score were significantly lower both in mothers with previous fractures and in their daughters, compared with respective values in mothers without fractures and their daughters. Future values in daughters were predicted using a stepwise, multiple regression analysis separately in the whole group and in the two subgroups. Future values were predicted in two models taking into consideration mothers' present SOS, BUA, and age or present SOS, BUA, and YSM. In both models, daughters' present SOS, BUA, age, height, and weight were taken into consideration. Predictive values were found to be high for daughters of women having had fractures (r = 0.72-0.87, p = 0.015-0.00007, SEE = 6.0-15.8) and lower for all daughters studied (r = 0.38-0.62, p = 0.03-0.0001, SEE = 8.8-21.5). In daughters of mothers without past fractures, prediction was not possible. Heritability of ultrasound values in daughters of women with past fractures ranged between 52% and 76%, whereas in the whole group the range was 14%-40%. In conclusion, the data indicate that, as a group, the daughters of women with osteoporotic fracture are likely to be at an increased risk for fractures because they have relatively low ultrasound values. Their future ultrasound values can be predicted on the basis of a single ultrasound evaluation with the condition that there is a history of maternal past fracture.
该研究的目的是建立母亲与女儿骨状态之间的关系。对48名绝经后女性及其48名绝经前女儿进行了评估。对整个组以及两个亚组进行了分析：27名健康母亲及其27名女儿；以及21名骨折母亲及其21名女儿。亚组在年龄和绝经年限（YSM）方面进行了匹配，身高、体重和体重指数（BMI）无显著差异。使用跟腱系统（Lunar，麦迪逊，威斯康星州）通过足跟超声测量评估骨状态，该系统测量声速（SOS [米/秒]）和宽带超声衰减（BUA [分贝/兆赫]）。跟腱软件还计算一个硬度指数（SI [%]）。与无骨折母亲及其女儿的相应值相比，既往有骨折的母亲及其女儿的BUA、SOS、硬度指数和Z评分的超声值均显著较低。在整个组和两个亚组中分别使用逐步多元回归分析预测女儿未来的值。在两个模型中考虑母亲当前的SOS、BUA和年龄或当前的SOS、BUA和YSM来预测未来的值。在两个模型中均考虑了女儿当前的SOS、BUA、年龄、身高和体重。发现有骨折女性的女儿的预测值较高（r = 0.72 - 0.87，p = 0.015 - 0.00007，SEE = 6.0 - 15.8），而所有研究女儿的预测值较低（r = 0.38 - 0.62，p = 0.03 - 0.0001，SEE = 8.8 - 21.5）。对于无既往骨折母亲的女儿，无法进行预测。既往有骨折女性的女儿中超声值的遗传度在52%至76%之间，而在整个组中范围为14% - 40%。总之，数据表明，作为一个群体，骨质疏松性骨折女性的女儿因超声值相对较低而可能骨折风险增加。在有母亲既往骨折史的情况下，基于单次超声评估可以预测她们未来的超声值。
