Tabor Elżbieta, Bach Małgorzata, Werner Aleksandra, Drozdzowska Bogna, Pluskiewicz Wojciech
Department and Clinic of Internal Diseases, Diabetology, and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Department of Applied Informatics, Silesian University of Technology, 44-100 Gliwice, Poland.
Biomedicines. 2022 Sep 22;10(10):2360. doi: 10.3390/biomedicines10102360.
The purpose of the research was to assess the genetic and environmental influences on bone properties. One hundred thirty-two pairs of twins (99/33 monozygotic/dizygotic) underwent anthropometric measurements and phalangeal quantitative ultrasound (DBM Sonic 1200, Igea, Italy) measuring the amplitude speed of sound (AD-SoS, m/s). The mean age was 16.78 ± 12.35 years for monozygotic twins and 14.30 ± 8 years for dizygotic. Interpair and intrapair correlations between twins were calculated. In the groups of monozygotic and dizygotic twins, Ad-SoS correlated significantly with age (r = 0.56−0.73, p < 0.05), weight (r = 0.73−0.78, p < 0.05), and height (r = 0.80−0.81, p < 0.05). The strongest intrapair correlation (r = 0.99−0.998) was noted in monozygotic females for Ad-SoS, weight, and height. There was a statistically significant correlation between the intrapair difference of Ad-SoS and age but only in the groups of monozygotic and dizygotic females (r = 0.281, r2 = 0.079, and p = 0.028; r = 0.544, r2 = 0.296, and p = 0.01, respectively). After age adjustment, it was estimated that 28.62% of Ad-SoS in women and 13.2% of Ad-SoS in men was explained by genetic influence, leading to the conclusion that Ad-SoS changed with age, weight, and height. The strongest correlation between pairs of twins was observed in monozygotic twins. The differences in bone values between female twins arose with age, which indicated the role of environmental factors.
该研究的目的是评估基因和环境对骨骼特性的影响。132对双胞胎（99对同卵双胞胎/33对异卵双胞胎）接受了人体测量以及指骨定量超声检查（DBM Sonic 1200，Igea，意大利），测量声速振幅（AD-SoS，米/秒）。同卵双胞胎的平均年龄为16.78±12.35岁，异卵双胞胎为14.30±8岁。计算了双胞胎之间的配对间和配对内相关性。在同卵和异卵双胞胎组中，AD-SoS与年龄（r = 0.56 - 0.73，p < 0.05）、体重（r = 0.73 - 0.78，p < 0.05）和身高（r = 0.80 - 0.81，p < 0.05）显著相关。在同卵双胞胎女性中，AD-SoS、体重和身高的配对内相关性最强（r = 0.99 - 0.998）。AD-SoS的配对内差异与年龄之间存在统计学显著相关性，但仅在同卵和异卵双胞胎女性组中（分别为r = 0.281，r2 = 0.079和p = 0.028；r = 0.544，r2 = 0.296和p = 0.01）。年龄调整后，估计女性中28.62%的AD-SoS和男性中13.2%的AD-SoS可由基因影响来解释，从而得出AD-SoS随年龄、体重和身高变化的结论。在同卵双胞胎中观察到双胞胎对之间的相关性最强。女性双胞胎之间的骨骼值差异随年龄增加，这表明了环境因素的作用。
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