柱孢属真菌将2,2'-双吗啡转化为新型化合物10-α-S-单羟基-2,2'-双吗啡和10,10'-α,α'-S,S'-二羟基-2,2'-双吗啡。
Transformation of 2,2'-bimorphine to the novel compounds 10-alpha-S-monohydroxy-2,2'-bimorphine and 10,10'-alpha,alpha'-S,S'-dihydroxy-2,2'-bimorphine by Cylindrocarpon didymum.
作者信息
Stabler P J, Holt P J, Bruce N C
机构信息
Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom.
出版信息
Appl Environ Microbiol. 2001 Aug;67(8):3716-9. doi: 10.1128/AEM.67.8.3716-3719.2001.
Abstract
Whole-cell suspensions of Cylindrocarpon didymum were observed to transform 2,2'-bimorphine to the compounds 10-alpha-S-monohydroxy-2,2'-bimorphine and 10,10'-alpha,alpha'-S,S'-dihydroxy-2,2'-bimorphine. Mass spectrometry and (1)H nuclear magnetic resonance spectroscopy confirmed the identities of these new morphine alkaloids.
摘要
观察到双孢柱孢霉的全细胞悬浮液可将2,2'-双吗啡转化为10-α-S-单羟基-2,2'-双吗啡和10,10'-α,α'-S,S'-二羟基-2,2'-双吗啡。质谱和¹H核磁共振光谱证实了这些新吗啡生物碱的结构。
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