余甘子根中的新型倍半萜类化合物。

Novel sesquiterpenoids from the roots of Phyllanthus emblica.

作者信息

Zhang Y J, Tanaka T, Iwamoto Y, Yang C R, Kouno I

机构信息

Faculty of Pharmaceutical Sciences, Nagasaki University, Bunkyo-Machi 1-14, Nagasaki 852-8521, Japan.

出版信息

J Nat Prod. 2001 Jul;64(7):870-3. doi: 10.1021/np010059z.

DOI:10.1021/np010059z

PMID:11473414

Abstract

Three novel bisabolane-type sesquiterpenoids, phyllaemblic acids B (1) and C (2) and phyllaemblicin D (3), together with two new phenolic glycosides, 2-carboxylmethylphenol 1-O-beta-D-glucopyranoside (4) and 2,6-dimethoxy-4-(2-hydroxyethyl)phenol 1-O-beta-D-glucopyranoside (5), were isolated from the roots of Phyllanthus emblica. The structures of 1-5 were established by spectral and chemical methods. The absolute stereochemistry of 1 and 2 was determined by applying the PGME method.

摘要

从余甘子根部分离得到三种新型没药烷型倍半萜类化合物，余甘子酸B（1）、余甘子酸C（2）和余甘子素D（3），以及两种新的酚苷，2-羧甲基苯酚1-O-β-D-吡喃葡萄糖苷（4）和2,6-二甲氧基-4-(2-羟乙基)苯酚1-O-β-D-吡喃葡萄糖苷（5）。通过光谱和化学方法确定了1-5的结构。采用PGME方法确定了1和2的绝对立体化学。