Hughes D E, Pugh G W
Am J Vet Res. 1975 Jul;36(7):1043-5.
A study was conducted to determine whether treatment devices could be designed for prolonged retention in the eyes of cattle. Experimental design ring devices were compared relative to their ease of insertion, induction of adverse tissue reaction, and period of retention. The ring devices were also compared with commercially available devices used in human eyes. Ring devices having a circumference smaller than that of the conjunctival sac, but larger than that of the globe of the eye, were easy to insert, caused a minimal tissue reaction, and were retained by the eye up to 19 days. The authors suggest that a development using the ring design and an erodable matrix containing an antibacterial agent could lead to a possible method for the treatment of obstinate infections, such as infectious bovine keratoconjunctivitis (IBK) and Moraxella bovis carrier states in cattle.
进行了一项研究，以确定是否可以设计出能长时间留存于牛眼内的治疗装置。对实验设计的环形装置在插入的难易程度、引发不良组织反应的情况以及留存时间方面进行了比较。这些环形装置还与用于人眼的市售装置进行了比较。周长小于结膜囊但大于眼球的环形装置易于插入，引起的组织反应极小，并且能在眼中留存长达19天。作者认为，利用环形设计以及含有抗菌剂的可侵蚀基质进行研发，可能会带来一种治疗顽固性感染的方法，比如牛传染性角膜结膜炎（IBK）以及牛莫拉菌携带状态。
