使用核体积测量技术估计婴儿猝死综合征病例中新皮质神经元的平均核体积。

Estimation of mean nuclear volume of neocortical neurons in sudden infant death syndrome cases using the nucleator estimator technique.

作者信息

Ansari T, Sibbons P D, Howard C V

机构信息

Department of Surgical Research, Northwick Park Institute of Medical Research, Northwick Park Hospital, Harrow, Mddx., UK.

出版信息

Biol Neonate. 2001 Jul;80(1):48-52. doi: 10.1159/000047119.

DOI:10.1159/000047119

PMID:11474149

Abstract

At present, no information is available with regards to either neocortical neuronal mean nuclear volume or maturation (functional or morphological) in abnormal paediatric brains. Using the nucleator estimator technique, the mean neocortical nuclear volume was estimated in sudden infant death syndrome (SIDS) cases [10 normal birth weight (NBW) and 10 low birth weight (LBW) cases classified by birth weight for gestational age] and compared to 10 NBW control cases. Both the control and SIDS LBW cases showed an increase in mean nuclear volume with age; the SIDS NBW cases showed no increase. At 8 months, the SIDS NBW cases showed a reduced mean nuclear volume (p = 0.02) when compared to controls. The SIDS LBW cases showed no statistically significant difference (p = 0.10) when compared with controls. A deficiency in mean neuronal nuclear volume may represent a deficiency in neuronal function.

摘要

目前，关于异常小儿大脑中的新皮质神经元平均核体积或成熟度（功能或形态）尚无可用信息。使用成核剂估算技术，在婴儿猝死综合征（SIDS）病例中（根据胎龄出生体重分类，10例正常出生体重（NBW）和10例低出生体重（LBW）病例）估算了新皮质平均核体积，并与10例NBW对照病例进行了比较。对照和SIDS LBW病例的平均核体积均随年龄增加；SIDS NBW病例则未增加。在8个月时，与对照组相比，SIDS NBW病例的平均核体积减小（p = 0.02）。与对照组相比，SIDS LBW病例无统计学显著差异（p = 0.10）。平均神经元核体积不足可能代表神经元功能不足。