Tellioglu T, Robertson D
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Auton Neurosci. 2001 Jun 20;89(1-2):96-9. doi: 10.1016/S1566-0702(01)00243-0.
Neurological manifestations are known to occur in patients with Behcet's Disease (BD) and significantly affect the clinical course of the disease. Nevertheless, the prevalence, pattern and severity of autonomic impairment in such patients have yet to be defined. In this paper, we presented a BD patient with orthostatic tachycardia. Non-invasive standardized autonomic function tests revealed no evidence of autonomic impairment, but profound orthostatic tachycardia accompanied by abnormal catecholamine increase was observed upon standing. The diagnosis of Orthostatic Intolerance (OI) was made and initial symptomatic therapy was started. The contribution of an immunological damage to components of neural pathways in the pathogenesis of the autonomic involvement can be assumed.
已知白塞病（BD）患者会出现神经学表现，且这些表现会显著影响疾病的临床进程。然而，此类患者自主神经功能障碍的患病率、模式及严重程度尚未明确。在本文中，我们报告了一名患有体位性心动过速的BD患者。非侵入性标准化自主神经功能测试未发现自主神经功能障碍的证据，但站立时观察到严重的体位性心动过速并伴有儿茶酚胺异常升高。诊断为体位性不耐受（OI）并开始了初始对症治疗。可以推测免疫损伤在自主神经受累发病机制中对神经通路成分的作用。
