Wang S, Dai R, Jin C
Huashan Hospital, Shanghai Medical University, Shanghai 200040.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998 Apr;18(4):204-7.
To test and verify the effect of artificial Shexiang Baoxin Pill (SXBXP, a heart protecting musk pill).
Two hundred and twenty-five patients of coronary heart disease (CHD) with angina pectoris were randomly and blindly assigned to the study group (112 cases) and the control group (113 cases). The two groups were well matched in age, sex, angina type, complication and grade of cardiac function. Two pills of artificial or natural SXBXP were given to each cases of the two groups for 3 times every day orally, for 2 weeks, respectively.
Both the artificial and natural SXBXP could not only reduce significantly the frequency of angina episode and the daily consumption of nitroglycerin, they also could result in remarkable improvement of NST, sigma ST and exercise tolerance, as well as significant reduction of rate-pressure product. The total symptomatic effective rate of the two groups was 86.6% and 89.4% respectively, and the ECG effective rate, 52.7% and 57.5% respectively (P > 0.05), and the incidence of headache of the two groups was one for eoch. In addition, the onset of action of both agents was rapid, 88.5% of the study group and 78.6% of the control group were within five minutes. The sustained time of action of the two groups was also similar, i.e. 4.9 +/- 4.4 h vs 5.4 +/- 3.1 h.
The clinical efficacy and side effect of artificial SXBXP were very similar to those of natural SXBXP.
检验并验证人工麝香保心丸（SXBXP，一种具有心脏保护作用的含麝香药丸）的效果。
将225例冠心病心绞痛患者随机、盲法分为研究组（112例）和对照组（113例）。两组在年龄、性别、心绞痛类型、并发症及心功能分级方面匹配良好。两组患者均口服人工或天然麝香保心丸，每次2丸，每日3次，各治疗2周。
人工和天然麝香保心丸均能显著降低心绞痛发作频率及硝酸甘油日用量，还能显著改善心电图ST段压低（NST）、ST段总偏移（sigma ST）及运动耐量，并显著降低心率-血压乘积。两组总症状有效率分别为86.6%和89.4%，心电图有效率分别为52.7%和57.5%（P>0.05），两组头痛发生率均为1例。此外，两种药物起效迅速，研究组88.5%、对照组78.6%的患者在5分钟内起效。两组药物作用持续时间也相似，分别为4.9±4.4小时和5.4±3.1小时。
人工麝香保心丸的临床疗效和副作用与天然麝香保心丸非常相似。
