Joseph B, Mulpuri K, Varghese G
Department of Orthopaedics, Kasturba Medical College, Manipal, Karnataka State, India.
J Bone Joint Surg Br. 2001 Jul;83(5):715-20. doi: 10.1302/0301-620x.83b5.10663.
We studied the natural history of Perthes' disease in 62 children in whom the onset of symptoms was in adolescence. Three patterns of disease were noted, namely, late-onset pattern, segmental collapse, or destructive with failure of revascularisation. In the late-onset pattern, the disease followed the sequence of healing seen in younger children, but adequate epiphyseal remodelling did not occur. Consequently, the femoral head was never spherical after revascularisation. With segmental collapse, early and irreversible collapse of part of the epiphysis occurred with gross deformation of the femoral head. The destructive pattern was characterised by a failure of revascularisation and repair of the avascular epiphysis. The radiological outcome was poor in all three patterns. The poorest clinical results were found in the destructive type which was frequently associated with incapacitating pain requiring arthrodesis or excision arthroplasty within three years of onset of the disease.
我们研究了62例症状始于青春期的儿童 Perthes 病的自然病史。观察到三种疾病模式,即晚发型、节段性塌陷或坏死性且无血管再生。在晚发型模式中,疾病遵循在年幼儿童中所见的愈合顺序,但未发生充分的骨骺重塑。因此,血管再生后股骨头从未呈球形。节段性塌陷时,骨骺的一部分早期发生不可逆塌陷,股骨头严重变形。坏死性模式的特征是无血管骨骺的血管再生和修复失败。所有三种模式的放射学结果均较差。在坏死性类型中临床结果最差,该类型常伴有严重疼痛,在疾病发作后三年内需要进行关节融合术或切除关节成形术。