Bauer H
MMW Munch Med Wochenschr. 1979 Aug 24;121(34):1085-8.
Whereas prospective studies seem to substantiate the efficacy of cimetidine treatment in the prophylaxis of acute gastrointestinal hemorrhage, communications on the therapeutic effect of cimetidine at the bleeding stage are contradictory. Our own experience is based on the treatment of 36 patients with acute hemorrhage of the upper gastrointestinal tract. Cimetidine was applied as a continuous drip, the objective being early operation when bleeding stopped, especially in peptic lesions. A primary cessation of bleeding was attained in all patients during the first 4 hours.
虽然前瞻性研究似乎证实了西咪替丁治疗在预防急性胃肠道出血方面的疗效,但关于西咪替丁在出血阶段治疗效果的报道却相互矛盾。我们自己的经验基于对36例上消化道急性出血患者的治疗。西咪替丁采用持续滴注的方式给药,目的是在出血停止后尽早进行手术,尤其是对于消化性病变。所有患者在最初4小时内均实现了出血的初步停止。