先天性巨结肠拖出术后胆汁酸排泄情况
Bile acid excretion after pull-through operation for Hirschsprung's disease.
作者信息
Gaze H, Murphy G M, Nelson R, Corkery J J, Anderson C M
出版信息
Arch Dis Child. 1975 Mar;50(3):243-5. doi: 10.1136/adc.50.3.243.
Four children with chronic diarrhoea and perianal excoriation after a pull-through operation for Hirschsprung's disease have been shown to have increased but not markedly raised levels of faecal bile acids. Bile acid analysis of the 'bile-rich' duodenal fluid obtained after pancreozymin stimulation in 3 of the patients indicated a marked reduction in the proportion of deoxycholic acid conjugates. These findings are compatible with colonic malabsorption of secondary bile acids in these patients which is related in some way to the pull-through operation, but which is not likely to be the cause of the diarrhoea and the anal excoriation.
4例患有先天性巨结肠症的儿童在经拖出式手术治疗后出现慢性腹泻和肛周皮肤擦伤，结果显示其粪便胆汁酸水平有所升高，但未显著升高。对其中3例患者在注射胰酶泌素后获得的“富含胆汁”的十二指肠液进行胆汁酸分析，结果表明脱氧胆酸共轭物的比例显著降低。这些发现与这些患者结肠对次级胆汁酸吸收不良相符，这在某种程度上与拖出式手术有关，但不太可能是腹泻和肛周皮肤擦伤的原因。
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