Gleadhill V, Bridges J M, Hadden D R
Arch Dis Child. 1975 Apr;50(4):318-20. doi: 10.1136/adc.50.4.318.
A patient with idiopathic marrow hypoplasia associated with short stature and other anomalies (Fanconi's anaemia) is described: treatment with human growth hormone for one year did not accelerate his growth rate or significantly affect his anaemia: androgen treatment considerably improved both features. Endocrine studies suggest that though he had poor and insufficient production of endogenous growth hormone to insulin-induced hypoglycaemia, the major defect in this syndrome is determined more at the end-organ than at the pituitary or gonadal level.
本文描述了一名患有特发性骨髓发育不全并伴有身材矮小及其他异常（范科尼贫血）的患者：使用人生长激素治疗一年，其生长速度未加快，贫血状况也未得到显著改善；雄激素治疗则使这两个症状均得到明显改善。内分泌研究表明，尽管该患者对胰岛素诱导的低血糖症产生内源性生长激素的能力较差且分泌不足，但此综合征的主要缺陷更多地取决于终末器官，而非垂体或性腺水平。
