Flowers N C, Hand R C, Horan L G
Arch Environ Health. 1975 Jul;30(7):353-60. doi: 10.1080/00039896.1975.10666719.
When respiratory alterations associated with the inhalation of aerosol propellants were eliminated, it was demonstrated that a ten-minute exposure to trichloromonofluoromethane (Freon 11) at concentrations below 15% never caused death. Rarely, at a concentration of exactly 15% minimal sinus slowing occurred (change less than 10% the base line rate). At concentrations between 15% and 17%, nine animals survived while seven succumbed. Ranges between 17.5% and 21% resulted in seven survivors of 19 animals, while no animal survived a ten-minute exposure to a concentration in excess of 21%. The mode of death was most commonly and ultimate asystole. Concentrations of dichlorodifluoromethane (Freon 12) greater than 95% were necessary to produce death in ten minutes, and severe oxygen deficit was evident.
当消除与吸入气溶胶推进剂相关的呼吸改变后，结果表明，在浓度低于15%的情况下，暴露于三氯一氟甲烷（氟利昂11）十分钟从未导致死亡。很少有情况是，在浓度恰好为15%时，出现轻微的窦性心动过缓（变化小于基线率的10%）。在15%至17%的浓度之间，9只动物存活，7只死亡。17.5%至21%的浓度范围使得19只动物中有7只存活，而在超过21%的浓度下暴露十分钟没有动物存活。死亡方式最常见的是最终出现心搏停止。要在十分钟内导致死亡，二氯二氟甲烷（氟利昂12）的浓度必须大于95%，并且明显存在严重的缺氧情况。
