Aviado D M
Toxicology. 1975;3(3):311-9. doi: 10.1016/0300-483x(75)90032-3.
The acute inhalational toxicity of trichlorofluoromethane (FC 11) is summarized in this paper. There is a striking similarity in threshold concentrations between the mouse and the rat on one hand and the dog and the monkey on the other. The mouse and rat require lower levels of concentration, i.e. (1 to 2.5%) to influence the respiratory system but higher levels (2.5 to 5.0%) to affect the circulatory system. The respiratory systems of the monkey and the dog have about the same sensitivity as those of the other two species in that the threshold level of FC 11 is 2.5 to 5%. The circulatory systems of the monkey and the dog can be influenced by a concentration of 0.5%.
本文总结了三氯氟甲烷（FC 11）的急性吸入毒性。一方面，小鼠和大鼠之间以及另一方面狗和猴之间的阈浓度存在显著相似性。小鼠和大鼠需要较低浓度水平（即1%至2.5%）来影响呼吸系统，但需要较高浓度水平（2.5%至5.0%）来影响循环系统。猴和狗的呼吸系统与其他两个物种的呼吸系统具有大致相同的敏感性，因为FC 11的阈水平为2.5%至5%。猴和狗的循环系统可受到0.5%浓度的影响。
